About LynxBio
Lynx Biosciences™, Inc. (LynxBio®) is a clinical-stage biotechnology company combining physiologically relevant suspension cell co-culture assays, automated microfluidics, and deep learning analytics with the goal of rapidly advancing drug candidates in oncology and bringing personalized cancer treatments to patients.
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As a (re)mission-driven company, we leverage this clinically-proven platform to address unmet medical needs in oncology, with an initial focus on hematological malignancies. To date, we have entered into collaborations with 10+ NCI-designated cancer centers as well as Top 20 pharmaceutical companies to advance promising drug candidates and identify predictive biomarkers in clinical studies.
Clinical partners
Programs
We are harnessing the power of our multi-omic platform to characterize complex diseases and treatments where suspension cells play critical roles, including hematological cancers, immunotherapies, and cell-based therapies.
Hematological cancers exhibit highly elaborate and heterogenous genotypic and cell signaling profiles while featuring limited actionable mutations. Additionally, the tumor microenvironment plays critical roles in the cancer cells’ behavior and response to drugs. By addressing these challenges in patient care and drug development, our approach has the unique potential [rephrase] to deliver powerful clarity of individual patients’ drug response and disease evolution.
Our Approach
Deep phenotypic profiling and functional characterization of suspension cells can be technically challenging due to their susceptibility to physical perturbations. At LynxBio, we drive innovation by combining proprietary, cutting-edge technologies with [established solutions], allowing us to [take] our understanding of factors that drive disease evolution and progression to new levels.
As a (re)mission-driven company, we leverage this clinically-proven platform to address unmet medical needs in oncology, with an initial focus on hematological malignancies. To date, we have entered into collaborations with 10+ NCI-designated cancer centers as well as Top 20 pharmaceutical companies to advance promising drug candidates and identify predictive biomarkers in clinical studies.
Publications
Biomicrofluidic Systems for Hematologic Cancer Research and Clinical Applications. [SLAS Technology 2019]
Integrating Population Heterogeneity Indices with Microfluidic Cell-Based Assays. [SLAS Discovery 2018]
Multiple Myeloma Cell Drug Responses Differ in Thermoplastic vs PDMS Microfluidic Devices. [J Vis Exp 2017]
Single cell functional analysis of multiple myeloma cell populations correlates with diffusion profiles in static microfluidic coculture systems. [Biomicrofluidics 2016, best paper award]
MicroC3: an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells. [Integr Biol 2015, cover article]
Microscale functional cytomics for studying hematologic cancers. [Blood 2012]